Aha! an illuminating perspective

AHA! : a connectionist perspective on problem solving

An Illuminating Counterexample

because S is “unbiased” and T 2 is “biased.” That means E(S) = σ 6= E(T ), i.e., an “unbiased estimator” is a statistic whose expected value is the quantity to be estimated. The goodness of an estimator is sometimes measured by the smallness of its “mean squared error,” defined as E ( ([estimator]− [quantity to be estimated]) ) . By that criterion the biased estimator T 2 would be better than t...

Occurrence of Cyclic di-GMP-Modulating Output Domains in Cyanobacteria: an Illuminating Perspective

UNLABELLED Microorganisms use a variety of metabolites to respond to external stimuli, including second messengers that amplify primary signals and elicit biochemical changes in a cell. Levels of the second messenger cyclic dimeric GMP (c-di-GMP) are regulated by a variety of environmental stimuli and play a critical role in regulating cellular processes such as biofilm formation and cellular m...

Revised Jones Criteria For The Diagnosis of Acute Rheumatic Fever (AHA 2015) - An Indian Perspective

Acute Rheumatic Fever (ARF) is still a major problem in some developing and low middle income countries though the incidence and prevalence has remarkably reduced in North America and Europe. Ever since T. Duckett Jones in 1944 proposed the Jones criteria, it was modified and later revised by the American Heart Association (AHA) in 1992. This was reconfirmed in and AHA sponsored Work shop in 20...

Lanthanide-tagged proteins--an illuminating partnership.

Lanthanide-tagged proteins are valuable for exploiting the unique properties of Ln ions for investigating protein structure, function, and dynamics. Introduction of the Ln into the target is accomplished via chemical modification with synthetic lanthanide-chelating prosthetic groups or by coexpression with peptide-based binding tags. Complexed Ln-tags offer a heavy-atom site for solving the pha...